The gameplay involves exploring rooms, gathering clues and items, solving puzzles and avoiding enemies in an effort to locate the missing puppies. The game takes place in DeVil Manor, a creepy and dangerous mansion filled with traps, puzzles and various obstacles that players need to overcome in order to progress through each level. In this game, players take on the role of Pongo and Perdita, two parent dogs trying to rescue their puppies from the clutches of Cruella de Vil. 101 Dalmatians: Escape From DeVil Manor is an adventure game based on the classic Disney movie of the same name.
